HBV Genotypic Variability in Cuba
نویسندگان
چکیده
The genetic diversity of HBV in human population is often a reflection of its genetic admixture. The aim of this study was to explore the genotypic diversity of HBV in Cuba. The S genomic region of Cuban HBV isolates was sequenced and for selected isolates the complete genome or precore-core sequence was analyzed. The most frequent genotype was A (167/250, 67%), mainly A2 (149, 60%) but also A1 and one A4. A total of 77 isolates were classified as genotype D (31%), with co-circulation of several subgenotypes (56 D4, 2 D1, 5 D2, 7 D3/6 and 7 D7). Three isolates belonged to genotype E, two to H and one to B3. Complete genome sequence analysis of selected isolates confirmed the phylogenetic analysis performed with the S region. Mutations or polymorphisms in precore region were more common among genotype D compared to genotype A isolates. The HBV genotypic distribution in this Caribbean island correlates with the Y lineage genetic background of the population, where a European and African origin prevails. HBV genotypes E, B3 and H isolates might represent more recent introductions.
منابع مشابه
Genetic variability and relationship of pod and seed traits in Pongamia Pinnata (L.) Pierre., a potential agroforestry tree
Screening of twenty-four candidate plus trees from naturally available Pongamia pinnata genetic resources was carried out to elucidate the genetic variation and relationship of pod and seed traits on germination capacity to select the best planting material for higher productivity. The experiment conducted at Forest Research Centre, Institute of Forest Productivity Mandar, Ranchi during 2005-20...
متن کاملGenotypic resistance to lamivudine among hepatitis B virus isolates in Mexico.
BACKGROUND Drug resistance of hepatitis B virus (HBV) is an increasing clinical problem. Resistance to lamivudine in HBV isolates in Mexico has been poorly explored. OBJECTIVES To characterize the mutation patterns associated with genotypic resistance to lamivudine and their prevalence among HBV isolates in Mexico. MATERIAL AND METHODS Thirty-nine Mexican HBV isolates were analysed by PCR a...
متن کاملGenotypic resistance profiles in Chinese patients with chronic hepatitis B virus infection and the efficacy of nucleoside analog rescue therapy
BACKGROUND AND AIMS The aims of this study were to explore the correlation between chronic hepatitis B virus (HBV) drug-resistant mutation profiles and the efficacy of nucleoside analog rescue therapy in patients with initial antiviral treatment failure. PATIENTS AND METHODS Patients with initial antiviral therapy failure were recruited between January 2011 and January 2013 from the Division ...
متن کاملThe KIF1B (rs17401966) single nucleotide polymorphism is not associated with the development of HBV-related hepatocellular carcinoma in Thai patients.
Hepatitis B virus (HBV) infection can become chronic and if left untreated can progress to hepatocellular carcinoma (HCC).Thailand is endemic for HBV and HCC is one of the top five cancers, causing deaths among Thai HBV-infected males. A single nucleotide polymorphism (SNP) at the KIF1B gene locus, rs17401966, has been shown to be strongly associated with the development of HBV-related HCC. How...
متن کاملVariability in wood properties of promising willow clones
The objective of the article is to investigate the variability in growth and wood properties of the willow clones. The growth and wood traits of four year old 21 clones willow clones were investigated. Analysis of variance showed that willow clones differed significantly for all the studied growth and wood traits. Among the growth parameters the maximum heritability value was shown by height wh...
متن کامل